New treatment could change many patient outcomes, expert says


(NewsNation) — A drug targeting a protein that drives breast cancer growth has been shown to work against tumors with very low levels of the protein. It is a development that Dr. Elizabeth Comen, medical oncologist at Memorial Sloan Kettering Cancer Center, calls “groundbreaking.”

It’s not a cure. But this latest gain for targeted cancer therapy could open new treatment possibilities to thousands of patients with advanced breast cancer.

Until now, breast cancers have been categorized as either HER2-positive — the cancer cells have more of the protein than normal — or HER2-negative. Doctors reporting the advance Sunday said it will make “HER2-low” a new category for guiding breast cancer treatment.

About half of patients with late-stage breast cancer formerly categorized as HER2-negative may actually be HER2-low and eligible for the drug.

The findings of the study “changes the treatment and potentially outcomes for about 50% of breast cancer patients living with metastatic disease,” Comen said. “We’re all just so excited about the new hope and promise of this medication for a large population of breast cancer patients.”

The drug is Enhertu, an antibody-chemotherapy combo given by IV. It finds and blocks the HER2 protein on cancer cells, while also unloading a powerful cancer-killing chemical inside those cells. It belongs to a relatively new class of drugs called antibody-drug conjugates.

The drug was already approved for HER2-positive breast cancer, and in April the Food and Drug Administration granted it breakthrough status for this new group of patients.

In the new study, the drug lengthened the time patients lived without their cancer progressing and improved survival compared with patients given standard chemotherapy.

The study compared Enhertu to standard chemo in about 500 patients with HER2-low breast cancer that had spread or could not be treated with surgery. The drug stopped the progress of cancer for about 10 months compared with about 5 1/2 months in the group getting regular care. The drug improved survival by about six months (from 17.5 months to 23.9 months).

“It’s a practice-changing study,” said Dr. Sylvia Adams, who directs breast cancer care at NYU Langone Health and enrolled several patients in the study. “It addresses a major unmet need for patients who have metastatic breast cancer.”

Now, it will be important to define the HER2 gray area to make sure the right patients receive the treatment and then to monitor them closely, experts said.

The drug, which costs about $14,000 a month, can have severe complications. Three patients in the study died of a lung disease that’s a known hazard of the drug. Doctors need to make sure patients report breathing problems right away so the drug can be stopped and patients treated with steroids.

The drug’s effectiveness for men with breast cancer is also a question mark, with Comen acknowledging experts continue to look at the male population in relation to the drug.

“We need to look more into male populations,” Comen said. “There are several 1000 men each year that are diagnosed with breast cancer. There are men that die from it as well every year in this country. So we certainly need to look more into this treatment for men. But if there is a man diagnosed with metastatic disease, we can certainly determine whether he has HER2-low metastatic breast cancer, and certainly this may be a viable option for him.”

Comen says the next step is ensuring the treatment is made available to as many people as possible.

“We need to push the FDA and insurance companies to make sure that this groundbreaking treatment is offered to patients not just at academic centers, but across the country and community practices as well,” Comen said. “It’s so important that patients have their pathology report ask to know ‘Am I heard too low?’ ‘Might this be a drug that I could be eligible to receive?’ Or do I need another biopsy to determine the nature of my breast cancer and if I might be eligible for the medication?”

The study findings were featured Sunday at the annual meeting of the American Society of Clinical Oncology in Chicago and published by the New England Journal of Medicine. Funding for the study came from Tokyo-based Daiichi Sankyo and U.K.-based AstraZeneca, which jointly developed the drug.

Patients take the drug until they can no longer tolerate it.

“A lot of people, including a lot of patients, will not have heard of HER2-low breast cancer before,” said the study’s lead author, Dr. Shanu Modi of Memorial Sloan Kettering Cancer Center in New York.

“We finally have a HER2-targeted drug that for the first time can target that low level of HER2 expression,” Modi said. “This drug actually helps to define HER2-low breast cancer. It makes it, for the first time, a targetable population.”

The Associated Press contributed to this report.

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