The fire broke out on the top floor of a six-story apartment building on 34th Avenue, near 90th Street around 1 p.m., according to the FDNY.
The fire quickly grew to six alarms, with more than 46 units and nearly 210 fire personnel responding to the scene.
At least four civilians and four firefighters suffered non-life-threatening injuries, according to the FDNY.
Firefighters and first responders were still on the scene as of 4:20 p.m.
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